Quinolines and derivatives
Apexbio Technology LLC GI-530159 69563-88-8 200mg
GI-530159 (CAS 69563-88-8) is a small molecule activator selective for the TREK1 and TREK2 two-pore domain potassium channels exhibiting greater specificity for TREK1/2 over other related channels such as TRAAK and TASK3 It has been shown to potentiate TREK1 channel activity with an EC50 of 0 76 M In experimental models GI-530159 reduces excitability in rat dorsal root ganglion neurons indicating its capability to modulate neuronal activity These properties highlight its utility as a pharmacological tool in studies related to neuronal excitability pain pathways and the pathophysiology of neurological disorders involving potassium channel dysfunction
Apexbio Technology LLC Fingolimod (FTY720) 162359-56-0 200mg
Fingolimod (FTY720 CAS 162359-56-0) is an orally administered sphingosine-1-phosphate (S1P) receptor agonist structurally analogous to natural sphingosine Originally derived from fungal metabolites and initially investigated in organ transplantation fingolimod interacts potently with receptors S1P1 S1P3 S1P4 and S1P5 (EC50 values approximately 0 3 3 1 nM) Its agonism promotes receptor internalization suppressing lymphocyte migration from lymph nodes into the circulation and central nervous system (CNS) Thus fingolimod is studied primarily for autoimmune disorders especially multiple sclerosis due to its effects on lymphocyte trafficking and CNS infiltration
Medchemexpress LLC Eltrombopag | 496775-61-2 | MFCD20926253 | C25H22N4O4 | 200 MG
Eltrombopag is an orally active thrombopoietin receptor nonpeptide agonist. It exhibits thrombopoietic activity and has been studied for low blood platelet counts in chronic immune thrombocytopenia. It is also used in cardiovascular research, shows strong inhibitory effects against multidrug-resistant Staphylococcus aureus, and can induce apoptosis in hepatocellular carcinoma (HCC).
- Exhibits thrombopoietic activity
- Used in research for low blood platelet counts in chronic immune thrombocytopenia
- Utilized in cardiovascular research
- Shows strong inhibitory effects against multidrug-resistant Staphylococcus aureus
- Can induce apoptosis in hepatocellular carcinoma (HCC)
Medchemexpress LLC Darunavir Ethanolate | 635728-49-3 | 99.9% | 593.73 | 200 MG
Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. It has a Ki of 1 nM for wild type HIV-1 protease.
- Broad-spectrum potent inhibitor active against HIV-1 clinical isolates with minimal cytotoxicity.
- Forms hydrogen bonds with the conserved main-chain atoms of Asp29 and Asp30 of the protease, critical for potency against HIV isolates resistant to multiple protease inhibitors.
- Shows greater potency than other inhibitors in MT-2 cells.
- Primarily metabolized by hepatic cytochrome P450 (CYP) enzymes, mainly CYP3A.
- Is effective against wild-type and PI-resistant HIV.
- Has an oral bioavailability of 37%, which increases to 82% when combined with ritonavir.
Medchemexpress LLC Sulfo-SPP | 452072-27-4 | 97.1% | 420.48 g·mol⁻1 | C14H16N2O7S3 | 5 MG
Sulfo-SPP is a heterobifunctional, thiol-cleavable, membrane-impermeable crosslinker used as an ADC linker in bioconjugation research. It reacts selectively with primary amines and contains a cleavable disulfide linkage that enables release under reducing conditions. Supplied for research use only.
- Heterobifunctional thiol-cleavable crosslinker.
- Membrane impermeable sulfonate group improves aqueous solubility.
- Cleavable disulfide linkage for controlled release under reducing conditions.
- Suitable for antibody-drug conjugate and bioconjugation applications.
- Available in small pack sizes for research use.
Apexbio Technology LLC Rosiglitazone(Synonyms: Avandia, BRL-49653, Rosiglitazone Maleate, Rosiglitazone Base, BRL49653C, RGZ, Rosiglizole), 200mg, CAS: 122320-73-4.
Rosiglitazone (CAS 122320-73-4) is a synthetic thiazolidinedione (TZD) that functions as an agonist of peroxisome proliferator-activated receptor gamma (PPAR ) a nuclear receptor highly expressed in adipose tissues Upon ligand binding PPAR forms heterodimers with retinoid X receptors promoting transcriptional activation of genes regulating adipogenesis glucose uptake lipid metabolism and insulin sensitivity Through modulating fatty acid storage in adipose tissue and secretion of adipokines rosiglitazone significantly enhances insulin sensitivity making it extensively utilized in metabolic and diabetes research particularly type II diabetes studies
Medchemexpress LLC NP118809 | 41332-24-5 | 98.73% | C₃₂H₃₂N₂O | 200 MG
NP118809 is a potent N-type calcium channel blocker with an IC₅₀ of 0.11 μM, and also inhibits L-type calcium channels less potently with an IC₅₀ of 12.2 μM. It is intended for research use only.
- Potent N-type calcium channel blocker (IC₅₀ of 0.11 μM).
- Inhibits L-type calcium channels (IC₅₀ of 12.2 μM).
- Shows significant analgesic activity in the phase IIA portions of the rat formalin model (25 mg/kg, i.p.).
- Results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model (30 mg/kg, p.o.).
- Available in solid form, light yellow to yellow in color.